Lineage Divergence at the First TCR-Dependent Checkpoint: Preferential gd and Impaired ab T Cell Development in Nonobese Diabetic Mice
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Lineage divergence at the first TCR-dependent checkpoint: preferential γδ and impaired αβ T cell development in nonobese diabetic mice.
The first TCR-dependent checkpoint in the thymus determines αβ versus γδ T lineage fate and sets the stage for later T cell differentiation decisions. We had previously shown that early T cells in NOD mice that are unable to rearrange a TCR exhibit a defect in checkpoint enforcement at this stage. To determine if T cell progenitors from wild-type NOD mice also exhibit cell-autonomous defects in...
متن کاملLineage divergence at the first TCR dependent checkpoint: preferential γδ and impaired αβ T cell development in non-obese diabetic (NOD) mice1
The first TCR-dependent checkpoint in the thymus determines αβ vs. γδ T lineage fate and sets the stage for later T cell differentiation decisions. We had previously shown that early T cells in NOD mice that are unable to rearrange a TCR exhibit a defect in checkpoint enforcement at this stage. To determine if T cell progenitors from wild type NOD mice also exhibit cell-autonomous defects in de...
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Natural development of diabetes in nonobese diabetic (NOD) mice requires both CD4 and CD8 T cells. Transgenic NOD mice carrying alphabeta TCR genes from a class I MHC (Kd)-restricted, pancreatic beta cell Ag-specific T cell clone develop diabetes significantly faster than nontransgenic NOD mice. In these TCR transgenic mice, a large fraction of T cells express both transgene derived and endogen...
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Two main lineages of T cells develop in the thymus: those that express the ab T-cell receptor (TCR) and those that express the gd TCR. Whereas the development, selection, and peripheral localization of newly differentiated ab T cells are understood in some detail, these processes are less well characterized in gd T cells. This review describes research carried out in this laboratory and others,...
متن کاملEither IL-2 or IL-12 is sufficient to direct Th1 differentiation by nonobese diabetic T cells.
Th cell differentiation from naive precursors is a tightly controlled process; the most critical differentiation factor is the action of the driving cytokine: IL-12 for Th1 development, IL-4 for Th2 development. We found that CD4(+) T cells from nonobese diabetic mice spontaneously differentiate into IFN-gamma-producing Th1 cells in response to polyclonal TCR stimulation in the absence of IL-12...
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تاریخ انتشار 2010